Yet Another Study Finds No Causal Link Between Tylenol & Autism

from the can-we-be-done-with-this? dept

As you will recall, the combination of RFK Jr.’s announcement that he’d find a root cause for all this autism going around combined with Donald Trump’s idiotic claim that there must be some external environmental cause of all this autism going around resulted in both of these clowns telling America that pregnant women taking Tylenol is causing all this autism going around. Never mind how dehumanizing this all is towards the many, many human beings who are on the autism spectrum, nor the other causes RFK Jr. has magically found for autism.

There is no scientific reason to believe that any causal link between autism and prenatal use of Tylenol exists. But that hasn’t stopped people with far too much faith in this particular government from refusing to take Tylenol. It also hasn’t stopped from governmental bootlickers making asses of themselves with lawsuits against Kenvue, makers of Tylenol. Not long after this bullshit announcement, even RFK Jr. acknowledged that there is no proven causal link to be had here.

But if that isn’t good enough for you, quality scientific studies continue to be performed and demonstrate that no link between Tylenol and autism can be found.

Another large study has found no link between autism and Tylenol use during pregnancy, refuting claims by President Trump and anti-vaccine Health Secretary Robert F. Kennedy Jr. In the new study published in JAMA Internal Medicine, researchers analyzed electronic health records from 2001 to 2023 for more than 700,000 pairs of mothers and children in Hong Kong. Of those pairs, about 43 percent of children had exposure to acetaminophen in utero.

The researchers saw no link between prenatal acetaminophen use and either condition. It didn’t matter what dosage of acetaminophen was taken, when it was taken during the pregnancy (which trimester), how often it was taken, or how old the mother was at the time. There was simply no link between acetaminophen and autism or ADHD.

Now, as has been the case with some previous studies, and what RFK Jr. and his cronies point to when they make this dumb claim, you do get some correlative linking if you drop the sibling-matched design and instead just correlate between prenatal Tylenol exposure and a diagnoses of autism. The problem is that if you perform what is called a “negative control” analysis, that link disappears again.

Interestingly, there was a link when the researchers dropped the sibling-matched design and instead compared acetaminophen-exposed with unexposed children, which is a finding that has come up in other studies. But when the researchers performed a “negative control” analysis and compared children whose mothers had taken acetaminophen before ever getting pregnant or after they had given birth compared to mothers who didn’t use the painkiller, they also saw an association—one that is “biologically implausible.”

The idea behind a negative control analysis is to analyze a cohort of conditions that should not produce the experimental result, an autism diagnosis in this case. When it does anyway, you know that the previously perceived link isn’t really there. In this case, instances in which a mother took Tylenol before or after pregnancy and had a child that was diagnosed with autism shows that what could have been thought to be a link between the two is actually more likely exposing family, genetic, or environmental factors that are resulting in both a child with autism and a trigger for the mother, or future mother, to be taking Tylenol.

This is what we mean when we say there is correlation, but not causation. It is still a useful clue, in other words, but not in the way that Trump and Kennedy would have you believe. It indicates that the mothers who have taken Tylenol are experiencing something that is a trigger for doing so and may indicate some associated reason for producing a child with autism.

In other words, just because the paint is peeling off your walls and there is a blaring sound going off in your ears doesn’t mean that the blaring sound caused the paint to peel. Your house is on fire, causing both paint to peel and the smoke alarms to go off.

Which, frankly, happens to be a wonderful analogy for what it’s like to have RFK Jr. in charge of public health.

Filed Under: autism, quacks, rfk jr., tylenol

Companies: kenvue